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The studies were investigated in the coma time and the survival time induced by KCN, the duration of breathing after decapitation, the survival time following ligation of both common carotid arteries and the survival time after it is treated for normobaric bypoxia with a nitrogen gas, a carbon dioxide gas or a vaccum in mice. The results were as follows: 1. In histotoxic anoxia, Moschus(0.4mg／kg, p.o) demonstrated a protective effect on coma induced by a sublethal dose of KCN(1.8mg／kg, i.v.) in mice. 2. Mice subjected to a lethal dose of KCN(3.0mg／kg, i.v.) did not die by administration of Moschus. 3. Moschus was significantly extended the duration of breathing after decapitation in mice. 4. Moschus showed a significant extension of survival time in mice following ligation of both common carotid arteries. 5. In the normobaric hypoxia with a nitrogen gas, Moschus showed a significant extension of survival time in mice. 6. In the normobaric hypoxia with a carbon dioxide gas, Moschus showed a significant shortness of survival time in mice. 7. In the normobaric hypoxia with a vaccum, Moschus showed a significant extension of survival time in mice. From the above results, it is suggested that Moschus demonstrated protective effects on the brain damages induced by cerebral anoxia.
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